A1 Refereed original research article in a scientific journal
Alternative solvents for electrophilic synthesis of 6-[F-18]fluoro-L-DOPA
Authors: Forsback S, Eskola O, Bergman J, Haaparanta M, Solin O
Publisher: WILEY-BLACKWELL
Publication year: 2009
Journal: Journal of Labelled Compounds and Radiopharmaceuticals
Journal name in source: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Journal acronym: J LABELLED COMPD RAD
Volume: 52
Issue: 7-8
First page : 286
Last page: 288
Number of pages: 3
ISSN: 0362-4803
DOI: https://doi.org/10.1002/jlcr.1599
Abstract
Owing to the ozone layer-depleting properties of chlorofluorocarbon compounds, alternative solvents for electrophilic fluorination reactions are desirable. Chloroform, dichloromethane, acetone or their deuterated analogues were examined as substitutes for Freon-11 in the electrophilic synthesis of 6-[F-18]fluoro-L-DOPA ([F-18]FDOPA). CDCl3, CD2Cl2 and C3D6O were found to be suitable solvents in this reaction, with the deuterated solvents providing significantly higher yields than Freon-11. There were no differences among the solvents in the specific radioactivity, the radiochemical purity, the chemical purity or the microbiological quality of the final product. However, the radiochemical yield of [F-18]FDOPA was increased when acetic acid was added to the precursor solution prior to the fluorination reaction.
Owing to the ozone layer-depleting properties of chlorofluorocarbon compounds, alternative solvents for electrophilic fluorination reactions are desirable. Chloroform, dichloromethane, acetone or their deuterated analogues were examined as substitutes for Freon-11 in the electrophilic synthesis of 6-[F-18]fluoro-L-DOPA ([F-18]FDOPA). CDCl3, CD2Cl2 and C3D6O were found to be suitable solvents in this reaction, with the deuterated solvents providing significantly higher yields than Freon-11. There were no differences among the solvents in the specific radioactivity, the radiochemical purity, the chemical purity or the microbiological quality of the final product. However, the radiochemical yield of [F-18]FDOPA was increased when acetic acid was added to the precursor solution prior to the fluorination reaction.
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