A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Prediction of detached personality in healthy subjects by low dopamine transporter binding
Tekijät: Laakso A, Vilkman H, Kajander J, Bergman J, Haaparanta M, Solin O, Hietala J
Kustantaja: AMER PSYCHIATRIC PRESS, INC
Julkaisuvuosi: 2000
Journal: American Journal of Psychiatry
Tietokannassa oleva lehden nimi: AMERICAN JOURNAL OF PSYCHIATRY
Lehden akronyymi: AM J PSYCHIAT
Vuosikerta: 157
Numero: 2
Aloitussivu: 290
Lopetussivu: 292
Sivujen määrä: 3
ISSN: 0002-953X
DOI: https://doi.org/10.1176/appi.ajp.157.2.290
Tiivistelmä
Objective: Low striatal dopamine D-2 receptor binding in healthy human subjects has been associated with detached personality in studies using positron emission tomography (PET) and the Karolinska Scales of Personality questionnaire. The authors investigated whether a similar correlation exists between striatal dopamine transporter binding and detached personality. Method: Eighteen healthy volunteers participated in a PET study with the specific dopamine transporter ligand [F-18]CFT ([F-18]WIN 35,428) and completed the Karolinska Scales of Personality questionnaire term. Results: Age-corrected dopamine transporter binding in the putamen, but not in the caudate, correlated negatively with detachment personality scores, especially in the right hemisphere. Conclusions: This finding supports the hypothesis that low dopaminergic neurotransmission is associated with detached personality. Furthermore, since [F-18]CFT binding is thought to reflect the density of dopaminergic nerve terminals in the brain, the authors suggest that the neurodevelopmental formation of the brain dopaminergic system may influence adult personality traits.
Objective: Low striatal dopamine D-2 receptor binding in healthy human subjects has been associated with detached personality in studies using positron emission tomography (PET) and the Karolinska Scales of Personality questionnaire. The authors investigated whether a similar correlation exists between striatal dopamine transporter binding and detached personality. Method: Eighteen healthy volunteers participated in a PET study with the specific dopamine transporter ligand [F-18]CFT ([F-18]WIN 35,428) and completed the Karolinska Scales of Personality questionnaire term. Results: Age-corrected dopamine transporter binding in the putamen, but not in the caudate, correlated negatively with detachment personality scores, especially in the right hemisphere. Conclusions: This finding supports the hypothesis that low dopaminergic neurotransmission is associated with detached personality. Furthermore, since [F-18]CFT binding is thought to reflect the density of dopaminergic nerve terminals in the brain, the authors suggest that the neurodevelopmental formation of the brain dopaminergic system may influence adult personality traits.
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