Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Prediction of detached personality in healthy subjects by low dopamine transporter binding

Julkaisun tekijät: Laakso A, Vilkman H, Kajander J, Bergman J, Haaparanta M, Solin O, Hietala J


Julkaisuvuosi: 2000

Journal: American Journal of Psychiatry

Tietokannassa oleva lehden nimi: AMERICAN JOURNAL OF PSYCHIATRY

Lehden akronyymi: AM J PSYCHIAT

Volyymi: 157

Julkaisunumero: 2

Sivujen määrä: 3

ISSN: 0002-953X


Objective: Low striatal dopamine D-2 receptor binding in healthy human subjects has been associated with detached personality in studies using positron emission tomography (PET) and the Karolinska Scales of Personality questionnaire. The authors investigated whether a similar correlation exists between striatal dopamine transporter binding and detached personality. Method: Eighteen healthy volunteers participated in a PET study with the specific dopamine transporter ligand [F-18]CFT ([F-18]WIN 35,428) and completed the Karolinska Scales of Personality questionnaire term. Results: Age-corrected dopamine transporter binding in the putamen, but not in the caudate, correlated negatively with detachment personality scores, especially in the right hemisphere. Conclusions: This finding supports the hypothesis that low dopaminergic neurotransmission is associated with detached personality. Furthermore, since [F-18]CFT binding is thought to reflect the density of dopaminergic nerve terminals in the brain, the authors suggest that the neurodevelopmental formation of the brain dopaminergic system may influence adult personality traits.

Last updated on 2021-24-06 at 10:31