A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
High levels of dopamine activity in the basal ganglia of cigarette smokers
Tekijät: Salokangas RKR, Vilkman H, Ilonen T, Taiminen T, Bergman J, Haaparanta M, Solin O, Alanen A, Syvalahti E, Hietala J
Kustantaja: AMER PSYCHIATRIC PRESS, INC
Julkaisuvuosi: 2000
Journal: American Journal of Psychiatry
Tietokannassa oleva lehden nimi: AMERICAN JOURNAL OF PSYCHIATRY
Lehden akronyymi: AM J PSYCHIAT
Vuosikerta: 157
Numero: 4
Aloitussivu: 632
Lopetussivu: 634
Sivujen määrä: 3
ISSN: 0002-953X
DOI: https://doi.org/10.1176/appi.ajp.157.4.632
Tiivistelmä
Objective: The authors' goal was to study presynaptic dopamine activity in smoking and nonsmoking human subjects in vivo. Method: [F-18]Fluorodopa ([F-18]DOPA) uptake K-i values in the basal ganglia of nine smoking and 10 nonsmoking healthy men were measured with positron emission tomography Results: Significantly higher [F-18]DOPA uptake was observed in both the putamen (average 17.3% higher) and the caudate (average 30.4% higher) of smokers than in those of nonsmokers. Conclusions: Smoking is related to greater dopamine activity in the human basal ganglia. Nicotine-induced dopamine activity may be a relevant mechanism in dependence on cigarette smoking.
Objective: The authors' goal was to study presynaptic dopamine activity in smoking and nonsmoking human subjects in vivo. Method: [F-18]Fluorodopa ([F-18]DOPA) uptake K-i values in the basal ganglia of nine smoking and 10 nonsmoking healthy men were measured with positron emission tomography Results: Significantly higher [F-18]DOPA uptake was observed in both the putamen (average 17.3% higher) and the caudate (average 30.4% higher) of smokers than in those of nonsmokers. Conclusions: Smoking is related to greater dopamine activity in the human basal ganglia. Nicotine-induced dopamine activity may be a relevant mechanism in dependence on cigarette smoking.
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