A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome
Tekijät: Ruottinen HM, Partinen M, Hublin C, Bergman J, Haaparanta M, Solin O, Rinne JO
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2000
Journal: Neurology
Tietokannassa oleva lehden nimi: NEUROLOGY
Lehden akronyymi: NEUROLOGY
Vuosikerta: 54
Numero: 2
Aloitussivu: 502
Lopetussivu: 504
Sivujen määrä: 3
ISSN: 0028-3878
DOI: https://doi.org/10.1212/WNL.54.2.502
Tiivistelmä
The authors investigated nine drug-naive patients with periodic limb movement disorder and restless legs syndrome (PLMD-RLS) and 27 healthy controls with PET using 6-[F-18]fluoro-L-dopa (FDOPA). In the patients, the FDOPA uptake (K-i(occ)) in the caudate nucleus was 88% and in the putamen 89% of the control mean values. This equal affection of the caudate and the putamen differs, for example, from the dopaminergic dysfunction in Parkinson's disease, which affects the putamen earlier and more severely than the caudate. The current results indicate mild nigrostriatal presynaptic dopaminergic hypofunction in PLMD-RLS.
The authors investigated nine drug-naive patients with periodic limb movement disorder and restless legs syndrome (PLMD-RLS) and 27 healthy controls with PET using 6-[F-18]fluoro-L-dopa (FDOPA). In the patients, the FDOPA uptake (K-i(occ)) in the caudate nucleus was 88% and in the putamen 89% of the control mean values. This equal affection of the caudate and the putamen differs, for example, from the dopaminergic dysfunction in Parkinson's disease, which affects the putamen earlier and more severely than the caudate. The current results indicate mild nigrostriatal presynaptic dopaminergic hypofunction in PLMD-RLS.
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