Obesity-associated intestinal insulin resistance is ameliorated after bariatric surgery - UTU Research Portal

A1 Refereed original research article in a scientific journal

Obesity-associated intestinal insulin resistance is ameliorated after bariatric surgery

Authors: Makinen J, Hannukainen JC, Karmi A, Immonen HM, Soinio M, Nelimarkka L, Savisto N, Helmio M, Ovaska J, Salminen P, Iozzo P, Nuutila P

Publisher: SPRINGER

Publication year: 2015

Journal: Diabetologia

Journal name in source: DIABETOLOGIA

Journal acronym: DIABETOLOGIA

Volume: 58

Issue: 5

First page : 1055

Last page: 1062

Number of pages: 8

ISSN: 0012-186X

eISSN: 1432-0428

DOI: https://doi.org/10.1007/s00125-015-3501-3

Abstract

Conclusions/interpretation This study shows that insulin is a potent stimulator of GU in the healthy intestine and that intestinal insulin resistance is ameliorated after bariatric surgery. In our study, obese individuals had intestinal insulin resistance regardless of their glycaemic status. Persistent changes in intestinal glucose metabolism are likely to influence both local processes in the gut and systemic glucose homeostasis.