A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
How to Assess Sensory Recovery After Breast Reconstruction Surgery?
Tekijät: Puonti HK, Broth TA, Soinila SO, Hallikainen HK, Jaaskelainen SK
Kustantaja: CIG MEDIA GROUP, LP
Julkaisuvuosi: 2017
Journal: Clinical Breast Cancer
Tietokannassa oleva lehden nimi: CLINICAL BREAST CANCER
Lehden akronyymi: CLIN BREAST CANCER
Vuosikerta: 17
Numero: 6
Aloitussivu: 471
Lopetussivu: 485
Sivujen määrä: 15
ISSN: 1526-8209
eISSN: 1938-0666
DOI: https://doi.org/10.1016/j.clbc.2017.04.011
Tiivistelmä
Clinical sensory examination was compared with quantitative neurophysiologic, psychophysical, and neuropathological tests in assessing sensory alterations in breasts reconstructed with innervated free flaps in breast cancer patients. Clinical examination was insensitive, whereas quantitative methods could confirm postoperative nerve injury after mastectomy and breast reconstruction. Psychophysical tests best identified sensory regeneration. Neurophysiologic and neuropathological investigations revealed differences between surgical techniques.Background: We evaluated clinical against psychophysical (tactile and thermal quantitative sensory test [QST]), neurophysiologic (somatosensory evoked potential [SEP]), and epithelial nerve fiber density (ENFD) examinations in detection and follow-up of sensory alterations after breast reconstruction done with or without nerve anastomoses. Patients and Methods: In a prospective 2-year follow-up design, 56 breast cancer patients underwent innervated and 20 patients noninnervated free rectus abdominis muscle-sparing flap (ms-TRAM) breast reconstruction. Healthy contralateral breasts (36 patients) and 20 healthy volunteer women served as control participants. The diagnostic values of clinical examination, QST, SEP, and ENFD tests were assessed at baseline, and 1 and 2 years postoperatively. Results: Sensation of mastectomized thoracic skin was impaired before reconstruction surgery, confirmed with QST (P < .001 for tactile, warm and cool detection; others not significant). All tests were further impaired at 1 year (P < .012-. 0001), but mostly showed improvement during subsequent follow-up (P <.001-. 0001), except for vibration and 2-point discrimination, ENFD, and SEP. QST improved diagnostic accuracy for large as well as small fiber function performing best in assessing sensory recovery at 2 years. Of clinical tests, sharp-blunt discrimination was modestly useful (sensitivity, 0.85; poor specificity, 0.17). Two-point and vibration discrimination tests had poor diagnostic values. SEP recording was modestly sensitive (0.50), but not specific (0.25). Because of sparse epithelial innervation already at baseline, ENFD performed poorly. Conclusion: Most tests could identify sensory nerve damage postoperatively. Tactile and thermal QST were most reliable, and sensitive also in confirming sensory recovery. SEP recording was useful especially in differentiating surgical techniques, whereas ENFD and clinical examination performed poorly, with the exception of sharp-blunt discrimination. (C) 2017 Elsevier Inc. All rights reserved.
Clinical sensory examination was compared with quantitative neurophysiologic, psychophysical, and neuropathological tests in assessing sensory alterations in breasts reconstructed with innervated free flaps in breast cancer patients. Clinical examination was insensitive, whereas quantitative methods could confirm postoperative nerve injury after mastectomy and breast reconstruction. Psychophysical tests best identified sensory regeneration. Neurophysiologic and neuropathological investigations revealed differences between surgical techniques.Background: We evaluated clinical against psychophysical (tactile and thermal quantitative sensory test [QST]), neurophysiologic (somatosensory evoked potential [SEP]), and epithelial nerve fiber density (ENFD) examinations in detection and follow-up of sensory alterations after breast reconstruction done with or without nerve anastomoses. Patients and Methods: In a prospective 2-year follow-up design, 56 breast cancer patients underwent innervated and 20 patients noninnervated free rectus abdominis muscle-sparing flap (ms-TRAM) breast reconstruction. Healthy contralateral breasts (36 patients) and 20 healthy volunteer women served as control participants. The diagnostic values of clinical examination, QST, SEP, and ENFD tests were assessed at baseline, and 1 and 2 years postoperatively. Results: Sensation of mastectomized thoracic skin was impaired before reconstruction surgery, confirmed with QST (P < .001 for tactile, warm and cool detection; others not significant). All tests were further impaired at 1 year (P < .012-. 0001), but mostly showed improvement during subsequent follow-up (P <.001-. 0001), except for vibration and 2-point discrimination, ENFD, and SEP. QST improved diagnostic accuracy for large as well as small fiber function performing best in assessing sensory recovery at 2 years. Of clinical tests, sharp-blunt discrimination was modestly useful (sensitivity, 0.85; poor specificity, 0.17). Two-point and vibration discrimination tests had poor diagnostic values. SEP recording was modestly sensitive (0.50), but not specific (0.25). Because of sparse epithelial innervation already at baseline, ENFD performed poorly. Conclusion: Most tests could identify sensory nerve damage postoperatively. Tactile and thermal QST were most reliable, and sensitive also in confirming sensory recovery. SEP recording was useful especially in differentiating surgical techniques, whereas ENFD and clinical examination performed poorly, with the exception of sharp-blunt discrimination. (C) 2017 Elsevier Inc. All rights reserved.
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