Maternal diabetes induces changes in the umbilical cord gene expression
: Koskinen A, Lehtoranta L, Laiho A, Laine J, Kaapa P, Soukka H
Publisher: W B SAUNDERS CO LTD
: 2015
: Placenta
: PLACENTA
: PLACENTA
: 36
: 7
: 767
: 774
: 8
: 0143-4004
DOI: https://doi.org/10.1016/j.placenta.2015.04.004(external)
Discussion: Maternal diabetic environment seems to alter umbilical cord expression of genes involved in the regulation of vascular development and function with simultaneous umbilical vessel muscle layer thickening. These alterations suggest vascular phenotypic modifications, which in turn may lead to long-term vascular consequences in various tissues in infants of diabetic mothers. (C) 2015 Elsevier Ltd. All rights reserved.