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Intestinal-Type Adenocarcinoma: Classification, Immunophenotype, Molecular Features and Differential Diagnosis
Tekijät: Ilmo Leivo
Kustantaja: SPRINGER
Julkaisuvuosi: 2017
Journal: Head and Neck Pathology
Tietokannassa oleva lehden nimi: HEAD & NECK PATHOLOGY
Lehden akronyymi: HEAD NECK PATHOL
Vuosikerta: 11
Numero: 3
Aloitussivu: 295
Lopetussivu: 300
Sivujen määrä: 6
ISSN: 1936-055X
DOI: https://doi.org/10.1007/s12105-017-0800-7
Tiivistelmä
Intestinal-type adenocarcinoma is the second most frequent sinonasal adenocarcinoma. High incidence of these tumors is seen among workers with occupational wood dust exposure, particularly of hardwood dusts. Intestinal-type adenocarcinoma has striking histomorphologic and immunophenotypic similarities with colorectal adenocarcinomas, but on the level of molecular pathologic mechanisms these tumors have their own specific features different from gastrointestinal tumors. This article provides an update on current histopathologic classification of intestinal-type adenocarcinomas, their immunophenotypic properties, recent advances in molecular pathologic features and differential diagnostic considerations.
Intestinal-type adenocarcinoma is the second most frequent sinonasal adenocarcinoma. High incidence of these tumors is seen among workers with occupational wood dust exposure, particularly of hardwood dusts. Intestinal-type adenocarcinoma has striking histomorphologic and immunophenotypic similarities with colorectal adenocarcinomas, but on the level of molecular pathologic mechanisms these tumors have their own specific features different from gastrointestinal tumors. This article provides an update on current histopathologic classification of intestinal-type adenocarcinomas, their immunophenotypic properties, recent advances in molecular pathologic features and differential diagnostic considerations.
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