A1 Refereed original research article in a scientific journal
Influence of Serotonin Transporter Gene Polymorphism (5-HTTLPR Polymorphism) on the Relation between Brain 5-HT Transporter Binding and Heart Rate Corrected Cardiac Repolarization Interval
Authors: Kauppila E, Vanninen E, Kaurijoki S, Karhunen L, Pietilainen KH, Rissanen A, Tiihonen J, Pesonen U, Kaprio J
Publisher: PUBLIC LIBRARY SCIENCE
Publishing place: SAN FRANCISCO; 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
Publication year: 2013
Journal: PLoS ONE
Journal name in source: Plos One
Journal acronym: PLoS One
Article number: e50303
Number in series: 1
Volume: 8
Issue: 1
Number of pages: 4
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0050303
Abstract
Objective: Serotonin transporter gene polymorphism (5-HTTLPR polymorphism) predicts the degree of structural and functional connectivity in the brain, and less consistently the degree of vulnerability for anxiety and depressive disorders. It is less known how 5-HTTLPR polymorphism influences on the coupling between brain and neuronal cardiovascular control. The present study demonstrates the impact of 5-HTTLPR polymorphism on the relations between heart rate (HR) corrected cardiac repolarization interval (QTc interval) and the brain 5-HTT binding. Material and Methods: Thirty healthy young adults (fifteen monozygotic twin pairs) (mean age 26 +/- 1.3 years, 16 females) were imagined with single-photon emission computed tomography (SPECT) using iodine-123 labeled 2 beta-carbomethoxy-3 beta-(4-iodophenyl) nortropane (nor-beta-CIT). Continuous ECG recording was obtained from each participant at supine rest. Signal averaged QTc interval on continuous ECG was calculated and compared with the brain imaging results. Results: In the two groups [l homozygotes (n = 16, 10 females), s carriers (n = 14, 8 female)] HR and the length of QTc interval were not influenced by 5-HTTLPR polymorphism. There were no significant relations between HR and 5-HTT binding in the brain. There were significant associations between QTc interval and nor-beta-CIT binding in the brain in l homozygotes, but not in s carriers (correlations for QTc interval and nor-beta-CIT binding of striatum, thalamus and right temporal region were -0.8--0.9, (p < 0.0005), respectively). Conclusion: The finding of longer QTc interval with less 5-HTT binding availability in major serotonergic binding sites in l homozygotes, but not in s carriers, implicate to differentiated control of QTc interval by 5-HTTLPR polymorphism.
Objective: Serotonin transporter gene polymorphism (5-HTTLPR polymorphism) predicts the degree of structural and functional connectivity in the brain, and less consistently the degree of vulnerability for anxiety and depressive disorders. It is less known how 5-HTTLPR polymorphism influences on the coupling between brain and neuronal cardiovascular control. The present study demonstrates the impact of 5-HTTLPR polymorphism on the relations between heart rate (HR) corrected cardiac repolarization interval (QTc interval) and the brain 5-HTT binding. Material and Methods: Thirty healthy young adults (fifteen monozygotic twin pairs) (mean age 26 +/- 1.3 years, 16 females) were imagined with single-photon emission computed tomography (SPECT) using iodine-123 labeled 2 beta-carbomethoxy-3 beta-(4-iodophenyl) nortropane (nor-beta-CIT). Continuous ECG recording was obtained from each participant at supine rest. Signal averaged QTc interval on continuous ECG was calculated and compared with the brain imaging results. Results: In the two groups [l homozygotes (n = 16, 10 females), s carriers (n = 14, 8 female)] HR and the length of QTc interval were not influenced by 5-HTTLPR polymorphism. There were no significant relations between HR and 5-HTT binding in the brain. There were significant associations between QTc interval and nor-beta-CIT binding in the brain in l homozygotes, but not in s carriers (correlations for QTc interval and nor-beta-CIT binding of striatum, thalamus and right temporal region were -0.8--0.9, (p < 0.0005), respectively). Conclusion: The finding of longer QTc interval with less 5-HTT binding availability in major serotonergic binding sites in l homozygotes, but not in s carriers, implicate to differentiated control of QTc interval by 5-HTTLPR polymorphism.
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