A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Botulinum toxin alleviates dysphagia of patients with inclusion body myositis
Tekijät: Schrey A, Airas L, Jokela M, Pulkkinen J
Kustantaja: ELSEVIER SCIENCE BV
Julkaisuvuosi: 2017
Journal: Journal of the Neurological Sciences
Tietokannassa oleva lehden nimi: JOURNAL OF THE NEUROLOGICAL SCIENCES
Lehden akronyymi: J NEUROL SCI
Vuosikerta: 380
Aloitussivu: 142
Lopetussivu: 147
Sivujen määrä: 6
ISSN: 0022-510X
DOI: https://doi.org/10.1016/j.jns.2017.07.031
Tiivistelmä
Objectives: Oropharyngeal dysphagia is a disabling and undertreated symptom that often occurs in patients with sporadic inclusion body myositis (s-IBM). In this study, we examined the effect of botulinum neurotoxin A (BoNT-A) injections to the cricopharyngeus muscle (CPM) of patients with s-IBM and dysphagia.Patients, materials and methods: A single-center retrospective study involving 40 biopsy-proven s-IBM-patients treated in the District of Southwest Finland from 2000 to 2013. The incidence of dysphagia, rate of aspirations, rate of aspiration pneumonias and treatment results of dysphagia were analyzed. Patients treated for dysphagia were evaluated before and after surgery by video -fluoroscopy and/or using a questionnaire.Results: Twenty-five of the 40 s -IBM patients (62.5%) experienced dysphagia. BoNT-A was injected a median of 2 times (range 1-7) in 12 patients with dysphagia. Before the injections 7 patients reported aspiration, none afterwards. The corresponding figures for aspiration pneumonia were 3 and 0. All of these patients had normal swallowing function 12 months (median, range 2-60) after the last injection.Conclusion: BoNT-A injections to the CPM alleviate the dysphagia of s-IBM patients reversibly and appear to reduce the rate of aspiration effectively. (C) 2017 Elsevier B.V. All rights reserved.
Objectives: Oropharyngeal dysphagia is a disabling and undertreated symptom that often occurs in patients with sporadic inclusion body myositis (s-IBM). In this study, we examined the effect of botulinum neurotoxin A (BoNT-A) injections to the cricopharyngeus muscle (CPM) of patients with s-IBM and dysphagia.Patients, materials and methods: A single-center retrospective study involving 40 biopsy-proven s-IBM-patients treated in the District of Southwest Finland from 2000 to 2013. The incidence of dysphagia, rate of aspirations, rate of aspiration pneumonias and treatment results of dysphagia were analyzed. Patients treated for dysphagia were evaluated before and after surgery by video -fluoroscopy and/or using a questionnaire.Results: Twenty-five of the 40 s -IBM patients (62.5%) experienced dysphagia. BoNT-A was injected a median of 2 times (range 1-7) in 12 patients with dysphagia. Before the injections 7 patients reported aspiration, none afterwards. The corresponding figures for aspiration pneumonia were 3 and 0. All of these patients had normal swallowing function 12 months (median, range 2-60) after the last injection.Conclusion: BoNT-A injections to the CPM alleviate the dysphagia of s-IBM patients reversibly and appear to reduce the rate of aspiration effectively. (C) 2017 Elsevier B.V. All rights reserved.
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