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Systemic Hypoxia Increases Circulating Concentration of Apelin in Humans
Tekijät: Heinonen I, Vuolteenaho O, Koskenvuo J, Arjamaa O, Nikinmaa M
Kustantaja: MARY ANN LIEBERT, INC
Julkaisuvuosi: 2017
Journal: High Altitude Medicine and Biology
Tietokannassa oleva lehden nimi: HIGH ALTITUDE MEDICINE & BIOLOGY
Lehden akronyymi: HIGH ALT MED BIOL
Vuosikerta: 18
Numero: 3
Aloitussivu: 292
Lopetussivu: 295
Sivujen määrä: 4
ISSN: 1527-0297
DOI: https://doi.org/10.1089/ham.2017.0017
Tiivistelmä
Heinonen, Ilkka, Olli Vuolteenaho, Juha Koskenvuo, Olli Arjamaa, and Mikko Nikinmaa. Systemic hypoxia increases circulating concentration of apelin in humans. High Alt Med Biol. 18: 292-295, 2017.Background: Apelin is a hormone that regulates cardiovascular function, and its concentration is increased by hypoxia based on cell culture and animal studies. As it remains unknown as to whether hypoxia could affect apelin levels in humans, we investigated whether breathing normobaric hypoxic gas mixture increases the circulating apelin concentration in healthy male subjects.Methods: Ten healthy young men (age 29+/-5 years, body mass index 24.7+/-2.8 kg/m(2)) breathed normobaric hypoxic gas mixture (11% O2/89% N-2) for 1 hour. Venous blood samples were obtained immediately before, and 2 and 24 hours after the start of the hypoxic exposure and analyzed for circulating apelin concentrations.Results: Arterial oxygen saturation decreased steadily from a baseline value of 99%+/-1% after the initiation hypoxia challenge and reached a steady-state level of 73%+/-6% within 20-30 minutes. Baseline apelin concentration was 3.3+/-1.3 pmol/L and remained comparable (3.3+/-1.4 pmol/L) to the baseline concentration at a 2-hour time point. However, apelin concentration at the 24-hour time point (5.5+/-2.8 pmol/L) was significantly (by * 67%) higher as compared with at both baseline and 2-hour time points (p < 0.05).Conclusion: In conclusion, in line with cell culture and animal studies, acute systemic hypoxia increases circulating apelin concentration also in humans.
Heinonen, Ilkka, Olli Vuolteenaho, Juha Koskenvuo, Olli Arjamaa, and Mikko Nikinmaa. Systemic hypoxia increases circulating concentration of apelin in humans. High Alt Med Biol. 18: 292-295, 2017.Background: Apelin is a hormone that regulates cardiovascular function, and its concentration is increased by hypoxia based on cell culture and animal studies. As it remains unknown as to whether hypoxia could affect apelin levels in humans, we investigated whether breathing normobaric hypoxic gas mixture increases the circulating apelin concentration in healthy male subjects.Methods: Ten healthy young men (age 29+/-5 years, body mass index 24.7+/-2.8 kg/m(2)) breathed normobaric hypoxic gas mixture (11% O2/89% N-2) for 1 hour. Venous blood samples were obtained immediately before, and 2 and 24 hours after the start of the hypoxic exposure and analyzed for circulating apelin concentrations.Results: Arterial oxygen saturation decreased steadily from a baseline value of 99%+/-1% after the initiation hypoxia challenge and reached a steady-state level of 73%+/-6% within 20-30 minutes. Baseline apelin concentration was 3.3+/-1.3 pmol/L and remained comparable (3.3+/-1.4 pmol/L) to the baseline concentration at a 2-hour time point. However, apelin concentration at the 24-hour time point (5.5+/-2.8 pmol/L) was significantly (by * 67%) higher as compared with at both baseline and 2-hour time points (p < 0.05).Conclusion: In conclusion, in line with cell culture and animal studies, acute systemic hypoxia increases circulating apelin concentration also in humans.
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