Early presentation of osteonecrosis in acute lymphoblastic leukemia: Two children from the Nordic and Baltic cohort

: Mogensen SS, Harila-Saari A, Frandsen TL, Lahteenmaki P, Castor A, Kohonen I, Schmiegelow K, Makitie O

Publisher: WILEY

: 2017

: Pediatric Blood and Cancer

: PEDIATRIC BLOOD & CANCER

: PEDIATR BLOOD CANCER

: ARTN e26624

: 64

: 11

: 4

: 1545-5009

: 1545-5017

DOI: https://doi.org/10.1002/pbc.26624

Osteonecrosis (ON) is usually considered treatment related in patients with acute lymphoblastic leukemia (ALL). We report two patients with presentation of ON at the time of ALL diagnosis. Both were females and diagnosed with ALL at age 8 and 14 years. In the latter, some symptoms and radiologically verified ON in both knees were still present after the end of ALL therapy. No pediatric patients have previously been reported with ON presenting before initiation of ALL therapy.