A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Late preterm birth has direct and indirect effects on infant gut microbiota development during the first six months of life
Tekijät: Forsgren M, Isolauri E, Salminen S, Rautava S
Kustantaja: WILEY
Julkaisuvuosi: 2017
Journal: Acta Paediatrica
Tietokannassa oleva lehden nimi: ACTA PAEDIATRICA
Lehden akronyymi: ACTA PAEDIATR
Vuosikerta: 106
Numero: 7
Aloitussivu: 1103
Lopetussivu: 1109
Sivujen määrä: 7
ISSN: 0803-5253
eISSN: 1651-2227
DOI: https://doi.org/10.1111/apa.13837
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/26733187
Aim: Preterm infants display aberrant gut microbial colonisation. We investigated whether the differences in gut microbiota between late preterm and full-term infants results from prematurity or external exposures.Methods: This study comprised 43 late preterm infants (34(0/7)-36(6/7)) and 75 full-term infants based on faecal samples collected following birth and at two to four weeks and six months of age. We assessed clinically relevant bacteria using quantitative polymerase chain reaction. Logistic regression analyses were performed to determine whether the observed differences in gut microbiota were attributable to prematurity or perinatal exposure.Results: The prevalence of bifidobacteria differed in the intestinal microbiota of the fullterm and late preterm neonates. Differences in the presence of specific species were detected at the age of six months, although the microbiota alterations were most prominent following delivery. As well as prematurity, the mode of birth, intrapartum and neonatal antibiotic exposure, and the duration of breastfeeding had an additional impact on gut microbiota development.Conclusion: The gut microbiota composition was significantly different between late preterm and full-term infants at least six months after birth. Antibiotic exposure was common in late preterm infants and modulated gut colonisation, but preterm birth also affected gut microbiota development independently.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
