A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Feeding Releases Endogenous Opioids in Humans
Tekijät: Tuulari JJ, Tuominen L, de Boer FE, Hirvonen J, Helin S, Nuutila P, Nummenmaa L
Kustantaja: SOC NEUROSCIENCE
Kustannuspaikka: WASHINGTON, DC
Julkaisuvuosi: 2017
Journal: Journal of Neuroscience
Tietokannassa oleva lehden nimi: JOURNAL OF NEUROSCIENCE
Lehden akronyymi: J NEUROSCI
Vuosikerta: 37
Numero: 34
Aloitussivu: 8284
Lopetussivu: 8291
Sivujen määrä: 8
ISSN: 0270-6474
eISSN: 0270-6474
DOI: https://doi.org/10.1523/JNEUROSCI.0976-17.2017
Tiivistelmä
The endogenous opioid system supports a multitude of functions related to appetitive behavior in humans and animals, and it has been proposed to govern hedonic aspects of feeding thus contributing to the development of obesity. Here we used positron emission tomography to investigate whether feeding results in hedonia-dependent endogenous opioid release in humans. Ten healthy males were recruited for the study. They were scanned with the mu-opioid-specific ligand [C-11] carfentanil three times, as follows: after a palatable meal, a nonpalatable meal, and after an overnight fast. Subjective mood, satiety, and circulating hormone levels were measured. Feeding induced significant endogenous opioid release throughout the brain. This response was more pronounced following a nonpalatable meal versus a palatable meal, and independent of the subjective hedonic responses to feeding. We conclude that feeding consistently triggers cerebral opioid release even in the absence of subjective pleasure associated with feeding, suggesting that metabolic and homeostatic rather than exclusively hedonic responses play a role in the feeding-triggered cerebral opioid release.
The endogenous opioid system supports a multitude of functions related to appetitive behavior in humans and animals, and it has been proposed to govern hedonic aspects of feeding thus contributing to the development of obesity. Here we used positron emission tomography to investigate whether feeding results in hedonia-dependent endogenous opioid release in humans. Ten healthy males were recruited for the study. They were scanned with the mu-opioid-specific ligand [C-11] carfentanil three times, as follows: after a palatable meal, a nonpalatable meal, and after an overnight fast. Subjective mood, satiety, and circulating hormone levels were measured. Feeding induced significant endogenous opioid release throughout the brain. This response was more pronounced following a nonpalatable meal versus a palatable meal, and independent of the subjective hedonic responses to feeding. We conclude that feeding consistently triggers cerebral opioid release even in the absence of subjective pleasure associated with feeding, suggesting that metabolic and homeostatic rather than exclusively hedonic responses play a role in the feeding-triggered cerebral opioid release.
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