A1 Journal article – refereed

Interaction of Pd2+ complexes of 2,6-disubstituted pyridines with nucleoside 5′-monophosphates




List of Authors: Oleg Golubev, Tuomas Lönnberg, Harri Lönnberg

Publisher: Elsevier

Publication year: 2014

Journal: Journal of Inorganic Biochemistry

Journal name in source: Journal of inorganic biochemistry

Journal acronym: J Inorg Biochem

Volume number: 139

Number of pages: 9

ISSN: 0162-0134

DOI: http://dx.doi.org/10.1016/j.jinorgbio.2014.05.013


Abstract

To learn more about the underlying principles of metal-ion-mediated recognition of nucleic acid bases, PdCl(+) complexes of six 2,6-disubstituted pyridines, viz. pyridine-2,6-dicarboxamide, its N(2),N(6)-dimethyl and N(2),N(6)-diisopropyl derivatives, 6-carbamoylpyridine-2-carboxylic acid, 6-aminomethylpyridine-2-carboxamide and its N(2)-methyl derivative, were prepared and their interaction with nucleoside 5'-monophosphate (NMP) was studied by (1)H NMR spectroscopy in D2O at pH7.2. The binding sites within the nucleobases were assigned on the basis of Pd(2+) induced changes in chemical shifts of the base moiety proton resonances. The mole fractions of NMPs engaged in mono- or dinuclear Pd(2+) complexes were determined at various concentrations by comparing the intensities of the aromatic and anomeric protons of the complexed and uncomplexed NMPs. Some of the pyridine complexes showed moderate discrimination between the NMPs.



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