A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Human reproduction and health: an evolutionary perspective




TekijätJasienska G, Bribiescas RG, Furberg AS, Helle S, Nunez-de la Mora A

KustantajaELSEVIER SCIENCE INC

Julkaisuvuosi2017

JournalLancet

Tietokannassa oleva lehden nimiLANCET

Lehden akronyymiLANCET

Vuosikerta390

Numero10093

Aloitussivu510

Lopetussivu520

Sivujen määrä11

ISSN0140-6736

eISSN1474-547X

DOIhttps://doi.org/10.1016/S0140-6736(17)30573-1


Tiivistelmä
According to life history theory, increased investment in reproductive function (physiology and behaviour) at different times throughout the life course affects the risk of many diseases and, ultimately, longevity. Although genetic factors contribute to interindividual and interpopulation variation in reproductive traits, the dominant source of variability is phenotypic plasticity during development and adult life. Reproductive traits in both sexes evolved sensitivity to ecological conditions, as reflected in contemporary associations of hormone concentrations with geographical setting, nutritional status, and physical activity level. Lifetime exposure to increased concentrations of sex hormones is associated with the risk of some cancers, hence decreasing fertility patterns contribute to secular increases in their incidence. Conversely, increased investment in reproductive function might compromise somatic investment in health, such that faster sexual maturation and higher parity increases risk of diabetes and cardiovascular disease. An evolutionary perspective on reproductive biology could improve the efficacy of public health efforts to reduce the risk of hormone-sensitive cancers and other non-communicable diseases.



Last updated on 2024-26-11 at 12:24