Article or data-article in scientific journal (B1)

Collagen Turnover in Wound Repair--A Macrophage Connection




List of AuthorsNissinen LM, Kähäri VM

PublisherNature Publishing Group

Publication year2015

JournalJournal of Investigative Dermatology

Journal acronymJ Invest Dermatol

Volume number135

Issue number10

Start page2350

End page2352

Number of pages3

ISSN0022-202X

DOIhttp://dx.doi.org/10.1038/jid.2015.246


Abstract

In this issue, Rohani et al. (2015) report on the role of macrophage-derived stromelysin-2 (matrix metalloproteinase (MMP)-10) in promoting the turnover of extracellular matrix (ECM) during cutaneous wound repair. They provide evidence that MMP-10 specifically enhances collagenolytic activity of murine MMP-13 produced by M2-like macrophages. These results emphasize the important role of macrophage-derived MMP-10 in regulating tissue remodeling and scar formation during wound healing.



Last updated on 2021-24-06 at 08:55