Article or data-article in scientific journal (B1)
Collagen Turnover in Wound Repair--A Macrophage Connection
List of Authors: Nissinen LM, Kähäri VM
Publisher: Nature Publishing Group
Publication year: 2015
Journal: Journal of Investigative Dermatology
Journal acronym: J Invest Dermatol
Volume number: 135
Issue number: 10
Start page: 2350
End page: 2352
Number of pages: 3
ISSN: 0022-202X
DOI: http://dx.doi.org/10.1038/jid.2015.246
In this issue, Rohani et al. (2015) report on the role of macrophage-derived stromelysin-2 (matrix metalloproteinase (MMP)-10) in promoting the turnover of extracellular matrix (ECM) during cutaneous wound repair. They provide evidence that MMP-10 specifically enhances collagenolytic activity of murine MMP-13 produced by M2-like macrophages. These results emphasize the important role of macrophage-derived MMP-10 in regulating tissue remodeling and scar formation during wound healing.