Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2)

Pyrophosphate-Fueled Na+ and H+ Transport in Prokaryotes




Julkaisun tekijätBaykov AA, Malinen AM, Luoto HH, Lahti R

KustantajaAMER SOC MICROBIOLOGY

Julkaisuvuosi2013

JournalMicrobiology and Molecular Biology Reviews

Tietokannassa oleva lehden nimiMICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Lehden akronyymiMICROBIOL MOL BIOL R

Numero sarjassa2

Volyymi77

Julkaisunumero2

Aloitussivu267

Lopetussivun numero276

Sivujen määrä10

ISSN1092-2172

DOIhttp://dx.doi.org/10.1128/MMBR.00003-13


Tiivistelmä
In its early history, life appeared to depend on pyrophosphate rather than ATP as the source of energy. Ancient membrane pyrophosphatases that couple pyrophosphate hydrolysis to active H+ transport across biological membranes (H+-pyrophosphatases) have long been known in prokaryotes, plants, and protists. Recent studies have identified two evolutionarily related and widespread prokaryotic relics that can pump Na+ (Na+-pyrophosphatase) or both Na+ and H+ (Na+,H+-pyrophosphatase). Both these transporters require Na+ for pyrophosphate hydrolysis and are further activated by K+. The determination of the three-dimensional structures of H+- and Na+-pyrophosphatases has been another recent breakthrough in the studies of these cation pumps. Structural and functional studies have highlighted the major determinants of the cation specificities of membrane pyrophosphatases and their potential use in constructing transgenic stress-resistant organisms.


Last updated on 2021-24-06 at 10:53