SynergyFinder: a web application for analyzing drug combination dose-response matrix data

: Ianevski A, He L, Aittokallio T, Tang J

Publisher: OXFORD UNIV PRESS

: 2017

: Bioinformatics

: BIOINFORMATICS

: 33

: 15

: 2413

: 2415

: 3

: 1367-4803

: 1460-2059

DOI: https://doi.org/10.1093/bioinformatics/btx162

Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the preclinical significance of pairwise drug combinations, functional screening assays that probe combination effects in a dose-response matrix assay are commonly used. To facilitate the analysis of such drug combination experiments, we implemented a web application that uses key functions of R-package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user-friendly interface for visualizing the drug combination landscapes in an interactive manner.