A1 Refereed original research article in a scientific journal

[F-18]FDG Accumulation in Early Coronary Atherosclerotic Lesions in Pigs




AuthorsMiikka Tarkia, Antti Saraste, Christoffer Stark, Tommi Vähäsilta, Timo Savunen, Marjatta Strandberg, Virva Saunavaara, Tuula Tolvanen, Jarmo Teuho, Mika Teräs, Olli Metsälä, Petteri Rinne, Ilkka Heinonen, Nina Savisto, Mikko Pietilä, Pekka Saukko, Anne Roivainen, Juhani Knuuti

PublisherPUBLIC LIBRARY SCIENCE

Publication year2015

JournalPLoS ONE

Journal name in sourcePLOS ONE

Journal acronymPLOS ONE

Article numberARTN e0131332

Volume10

Issue6

Number of pages15

ISSN1932-6203

DOIhttps://doi.org/10.1371/journal.pone.0131332


Abstract

We found increased uptake of [F-18]FDG in coronary atherosclerotic lesions in a pig model. However, uptake in these early stage lesions was not detectable with in vivo PET imaging. Further studies are needed to clarify whether visible [F-18]FDG uptake in coronary arteries represents more advanced, highly inflamed plaques.


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