Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Exercise Training Reduces Intrathoracic Fat Regardless of Defective Glucose Tolerance




Julkaisun tekijät: Sanna M. Honkala, Kumail K. Motiani, Jari-Joonas Eskelinen, Anna Savolainen, Virva Saunavaara, Kirsi A. Virtanen, Eliisa Löyttyniemi, Jukka Kapanen, Juhani Knuuti, Kari K. Kalliokoski, Jarna C. Hannukainen

Kustantaja: LIPPINCOTT WILLIAMS & WILKINS

Julkaisuvuosi: 2017

Journal: Medicine and Science in Sports and Exercise

Tietokannassa oleva lehden nimi: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Lehden akronyymi: MED SCI SPORT EXER

Volyymi: 49

Julkaisunumero: 7

Sivujen määrä: 10

ISSN: 0195-9131

eISSN: 1530-0315

DOI: http://dx.doi.org/10.1249/MSS.0000000000001232


Tiivistelmä
Purpose: Epicardial (EAT) and pericardial (PAT) fat masses and myocardial triglyceride content (MTC) are enlarged in obesity and insulin resistance. We studied whether the high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) similarly decrease ectopic fat in and around the heart and whether the decrease is similar in healthy subjects and subjects with defective glucose tolerance (DGT).Methods: A total of 28 healthy men (body mass index = 20.7-30.0 kg.m(-2), age = 40-55 yr) and 16 men with DGT (body mass index = 23.8-33.5 kg.m(-2), age = 43-53 yr) were randomized into HIIT and MICT interventions for 2 wk. EAT and PAT were determined by computed tomography and MTC by H-1-MRS.Results: At baseline, DGT subjects had impaired aerobic capacity and insulin sensitivity and higher levels of whole body fat, visceral fat, PAT, and EAT (P < 0.05, all) compared with healthy subjects. In the whole group, HIIT increased aerobic capacity (HIIT = 6%, MICT = 0.3%; time x training P = 0.007) and tended to improve insulin sensitivity (HIIT = 24%, MICT = 8%) as well as reduce MTC (HIIT = -42%, MICT = +23%) (time x training P = 0.06, both) more efficiently compared with MICT, and without differences in the training response between the healthy and the DGT subjects. However, both training modes decreased EAT (-5%) and PAT (-6%) fat (time P < 0.05) and not differently between the healthy and the DGT subjects.Conclusion: Whole body fat, visceral fat, PAT, and EAT masses are enlarged in DGT. Both HIIT and MICT effectively reduce EAT and PAT in healthy and DGT subjects, whereas HIIT seems to be superior as regards improving aerobic capacity, whole-body insulin sensitivity, and MTC.


Last updated on 2021-24-06 at 09:16