A1 Refereed original research article in a scientific journal
Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells
Authors: Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Soderstrom M, Emani MR, Stubb A, Narva E, Ghimire B, Laiho A, Jarvelainen H, Lahesmaa R, Lahdesmaki H, Hawkins RD, Lund RJ
Publisher: NATURE PUBLISHING GROUP
Publication year: 2016
Journal: Scientific Reports
Journal name in source: SCIENTIFIC REPORTS
Journal acronym: SCI REP-UK
Article number: ARTN 22190
Volume: 6
Number of pages: 8
ISSN: 2045-2322
DOI: https://doi.org/10.1038/srep22190
Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel insight into the mechanisms associated with spontaneous transformation of human pluripotent stem cells towards malignant fate. The same mechanisms may control the genomic stability of cells in somatic tissues.