A1 Journal article – refereed

Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells




List of Authors: Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Soderstrom M, Emani MR, Stubb A, Narva E, Ghimire B, Laiho A, Jarvelainen H, Lahesmaa R, Lahdesmaki H, Hawkins RD, Lund RJ

Publisher: NATURE PUBLISHING GROUP

Publication year: 2016

Journal: Scientific Reports

Journal name in source: SCIENTIFIC REPORTS

Journal acronym: SCI REP-UK

Volume number: 6

Number of pages: 8

ISSN: 2045-2322

DOI: http://dx.doi.org/10.1038/srep22190


Abstract

Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel insight into the mechanisms associated with spontaneous transformation of human pluripotent stem cells towards malignant fate. The same mechanisms may control the genomic stability of cells in somatic tissues.


Last updated on 2021-24-06 at 10:55