A1 Refereed original research article in a scientific journal

Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells




AuthorsKonki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Soderstrom M, Emani MR, Stubb A, Narva E, Ghimire B, Laiho A, Jarvelainen H, Lahesmaa R, Lahdesmaki H, Hawkins RD, Lund RJ

PublisherNATURE PUBLISHING GROUP

Publication year2016

JournalScientific Reports

Journal name in sourceSCIENTIFIC REPORTS

Journal acronymSCI REP-UK

Article numberARTN 22190

Volume6

Number of pages8

ISSN2045-2322

DOIhttps://doi.org/10.1038/srep22190


Abstract

Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel insight into the mechanisms associated with spontaneous transformation of human pluripotent stem cells towards malignant fate. The same mechanisms may control the genomic stability of cells in somatic tissues.



Last updated on 2024-26-11 at 23:31