Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction



: Hagelberg NM, Saarikoski T, Saari TI, Neuvonen M, Neuvonen PJ, Turpeinen M, Scheinin M, Laine K, Olkkola KT

Publisher: SPRINGER HEIDELBERG

: 2013

: European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 4

: 69

: 4

: 867

: 875

: 9

: 0031-6970

DOI: https://doi.org/10.1007/s00228-012-1433-0


Ticlopidine increased exposure to tramadol, reduced its renal clearance and inhibited the formation of M1, most likely via inhibition of CYP2B6 and/or CYP2D6. The addition of itraconazole to ticlopidine did not modify the outcome of the drug interaction. Concomitant clinical use of ticlopidine and tramadol may enhance the risk of serotonergic effects, especially when higher doses of tramadol are used.



Last updated on 2024-26-11 at 18:11