Lipidomics in biomedical research-practical considerations

: Hyotylainen T, Ahonen L, Poho P, Oresic M

Publisher: ELSEVIER SCIENCE BV

: 2017

: Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids

: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

: BBA-MOL CELL BIOL L

: 1862

: 8

: 800

: 803

: 4

: 1388-1981

: 0006-3002

DOI: https://doi.org/10.1016/j.bbalip.2017.04.002

Lipids have many central physiological roles including as structural components of cell membranes, energy storage sources and intermediates in signaling pathways. Lipid-related disturbances are known to underlie many diseases and their co-morbidities. The emergence of lipidomics has empowered researchers to study lipid metabolism at the cellular as well as physiological levels at a greater depth than was previously possible. The key challenges ahead in the field of lipidomics in medical research lie in the development of experimental protocols and in silico techniques needed to study lipidomes at the systems level. Clinical questions where lipidomics may have an impact in healthcare settings also need to be identified, both from the health outcomes and health economics perspectives. This article is part of a Special Issue entitled: BBALIP_Lipidomics Opinion Articles edited by Sepp Kohlwein.