Artificial ribonucleases

: Niittymaki T, Lonnberg H

Publisher: ROYAL SOC CHEMISTRY

: 2006

ORGANIC & BIOMOLECULAR CHEMISTRY

: ORG BIOMOL CHEM

: 4

: 1

: 15

: 25

: 11

: 1477-0520

DOI: https://doi.org/10.1039/b509022a

Mimicking the action of enzymes by simpler and more robust man-made catalysts has long inspired bioorganic chemists.(1) During the past decade, mimics for RNA- cleaving enzymes, ribonucleases,(2) or, more precisely, mimics of ribozymes(3) that cleave RNA in sequence-selective rather than base- selective manner, have received special attention. These artificial ribonucleases are typically oligonucleotides ( or their structural analogs) that bear a catalytically active conjugate group and catalyze sequence-selective hydrolysis of RNA phosphodiester bonds.

Chemical sciences