A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
DEPURINATION OF (DIEN)PT(II) COMPLEXES OF PURINE DEOXYRIBONUCLEOSIDES - COMPARISON WITH THE EFFECTS OF (DIEN)PD(II) ION COMPLEXING
Tekijät: ARPALAHTI J, JOKILAMMI A, HAKALA H, LONNBERG H
Kustantaja: JOHN WILEY & SONS LTD
Julkaisuvuosi: 1991
Lehti:: Journal of Physical Organic Chemistry
Tietokannassa oleva lehden nimi: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
Lehden akronyymi: J PHYS ORG CHEM
Vuosikerta: 4
Numero: 5
Aloitussivu: 301
Lopetussivu: 309
Sivujen määrä: 9
ISSN: 0894-3230
DOI: https://doi.org/10.1002/poc.610040507
Tiivistelmä
First-order rate constants for the hydrolytic depurination of 2'-deoxyinosine and its various (dien)Pt(II) ion complexes were measured over the acidic pH range. The rate profiles obtained indicate that the uncomplexed nucleoside and its N1-(dien)Pt(II) complex are depurinated via mono- and di-protonated species, whereas the N7-(dien)Pt(II) and N1,N7-di(dien)Pt(II) complexes exhibit significant spontaneous hydrolysis, which competes with a markedly retarded acid-catalysed reaction. Rate constants for the various partial reactions were calculated and the results were employed to explain the effects that (dien)Pd(II) ion exerted on depurination rates of the same compounds. Similar measurements were carried out with the N1,N7-di(dien)Pt(II) complex of 2'-deoxyadenosine in order to further the understanding of the previously reported rate-enhancing effect of (dien)Pd(II) ion on the depurination of 2'-deoxyadenosine.
First-order rate constants for the hydrolytic depurination of 2'-deoxyinosine and its various (dien)Pt(II) ion complexes were measured over the acidic pH range. The rate profiles obtained indicate that the uncomplexed nucleoside and its N1-(dien)Pt(II) complex are depurinated via mono- and di-protonated species, whereas the N7-(dien)Pt(II) and N1,N7-di(dien)Pt(II) complexes exhibit significant spontaneous hydrolysis, which competes with a markedly retarded acid-catalysed reaction. Rate constants for the various partial reactions were calculated and the results were employed to explain the effects that (dien)Pd(II) ion exerted on depurination rates of the same compounds. Similar measurements were carried out with the N1,N7-di(dien)Pt(II) complex of 2'-deoxyadenosine in order to further the understanding of the previously reported rate-enhancing effect of (dien)Pd(II) ion on the depurination of 2'-deoxyadenosine.
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