A2 Refereed review article in a scientific journal
Biotechnology of the medicinal plant Rhazya stricta: a little investigated member of the Apocynaceae family
Authors: Akhgari Amir, Oksman-Caldentey Kirsi-Marja, Rischer Heiko
Publisher: SPRINGER
Publication year: 2017
Journal: Biotechnology Letters
Journal name in source: BIOTECHNOLOGY LETTERS
Journal acronym: BIOTECHNOL LETT
Volume: 39
Issue: 6
First page : 829
Last page: 840
Number of pages: 12
ISSN: 0141-5492
eISSN: 1573-6776
DOI: https://doi.org/10.1007/s10529-017-2320-7
Abstract
Rhazya stricta Decne. (Apocynaceae) is an important medicinal plant that is widely distributed in the Middle East and Indian sub-continent. It produces a large number of terpenoid indole alkaloids (TIAs) some of which possess important pharmacological properties. However, the yields of these compounds are very low. Establishment of a reliable, reproducible and efficient transformation method and induction of hairy roots system is a vital prerequisite for application of biotechnology in order to improve secondary metabolite yields. In the present review, recent biotechnological attempts and advances in TIAs production through transformed hairy root cultures in R. stricta are reviewed to draw the attention to its metabolic engineering potential.
Rhazya stricta Decne. (Apocynaceae) is an important medicinal plant that is widely distributed in the Middle East and Indian sub-continent. It produces a large number of terpenoid indole alkaloids (TIAs) some of which possess important pharmacological properties. However, the yields of these compounds are very low. Establishment of a reliable, reproducible and efficient transformation method and induction of hairy roots system is a vital prerequisite for application of biotechnology in order to improve secondary metabolite yields. In the present review, recent biotechnological attempts and advances in TIAs production through transformed hairy root cultures in R. stricta are reviewed to draw the attention to its metabolic engineering potential.
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