Stent-oriented versus patient-oriented outcome in patients undergoing early percutaneous coronary intervention for acute coronary syndrome – 2-year report from the BASE-ACS trial - UTU Research Portal

A1 Refereed original research article in a scientific journal

Stent-oriented versus patient-oriented outcome in patients undergoing early percutaneous coronary intervention for acute coronary syndrome – 2-year report from the BASE-ACS trial

Subtitle: 2-year report from the BASE-ACS trial

Authors: Romppanen H, Nammas W, Kervinen K, Airaksinen JKE, Pietila M, Rivero-Crespo F, DeBelder A, Tedjokusumo P, Mikkelsson J, Ylitalo A, Karjalainen PP

Publisher: INFORMA HEALTHCARE

Publishing place: NEW YORK; 52 VANDERBILT AVE, NEW YORK, NY 10017 USA

Publication year: 2013

Journal: Annals of Medicine

Journal name in source: Annals of Medicine

Journal acronym: Ann.Med.

Number in series: 7

Volume: 45

Issue: 7

First page : 488

Last page: 493

Number of pages: 6

ISSN: 0785-3890

DOI: https://doi.org/10.3109/07853890.2013.833390

Abstract

Background. The BASE-ACS trial demonstrated an outcome of the titanium-nitride-oxide-coated bioactive stents (BAS) statistically non-inferior to that of the everolimus-eluting stents (EES) at 12-month follow-up in patients presenting with acute coronary syndrome (ACS). We performed a post hoc analysis of the BASE-ACS trial with particular focus on stent-oriented versus patient-oriented outcome at 24-month follow-up.

Methods. A total of 827 patients with ACS were randomly assigned to receive either BAS (417) or EES (410). Stent-oriented outcome was defined as a composite of cardiac death, target vessel-related non-fatal myocardial infarction, or ischemia-driven target lesion revascularization. Patient-oriented outcome was defined as a composite of all-cause death, any non-fatal myocardial infarction, or any revascularization.

Results. Clinical follow-up for 24 months was completed in 406 (97.4%) patients in the BAS group and in 398 (97.1%) in the EES group. Stent-oriented outcome at 24-month follow-up occurred at similar frequencies in the two stent groups (10.1% for BAS versus 11.2% for EES, P = 0.53). Likewise, patient-oriented outcome at 24-month follow-up was similar in the two groups (16.3% versus 19.8%, respectively, P = 0.2).

Conclusions. In patients presenting with ACS, the rates of both stent-oriented and patient-oriented outcomes at 24-month follow-up in the BAS group were similar to those in the EES group.