A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
The Spectrum of Genital Human Papillomavirus Infection Among Men Attending a Swedish Sexually-transmitted Infections Clinic: Human Papillomavirus Typing and Clinical Presentation of Histopathologically Benign Lesions
Tekijät: Wikstrom A, Vassilaki I, Hedblad MA, Syrjanen S
Kustantaja: ACTA DERMATO-VENEREOLOGICA
Julkaisuvuosi: 2013
Journal: Acta Dermato-Venereologica
Tietokannassa oleva lehden nimi: ACTA DERMATO-VENEREOLOGICA
Lehden akronyymi: ACTA DERM-VENEREOL
Numero sarjassa: 2
Vuosikerta: 93
Numero: 2
Aloitussivu: 223
Lopetussivu: 227
Sivujen määrä: 5
ISSN: 0001-5555
DOI: https://doi.org/10.2340/00015555-1375
Tiivistelmä
There have been a number of Swedish studies on human papillomavirus (HPV) typing in men, most of which have used less sensitive HPV-typing techniques. The present study included male patients with genital HPV-induced lesions planned for surgery. Samples were prepared for histopathology and PCR. HPV was detected in 233/253 (92%) and HPV 6 or 11 in 89% of the HPV-positive lesions. There were statistically significant differences regarding morphology (p=0.002), location (p=0.000001) and colour (p=0.005) of the lesions for low- vs. mixed or high-risk HPV types. For example, acuminate lesions were mostly found among men with low-risk HPV types, whereas macular lesions were over-represented among them with mixed or high-risk types. The HPV type distribution is similar to that in earlier studies, but we also found correlations with some clinical parameters.
There have been a number of Swedish studies on human papillomavirus (HPV) typing in men, most of which have used less sensitive HPV-typing techniques. The present study included male patients with genital HPV-induced lesions planned for surgery. Samples were prepared for histopathology and PCR. HPV was detected in 233/253 (92%) and HPV 6 or 11 in 89% of the HPV-positive lesions. There were statistically significant differences regarding morphology (p=0.002), location (p=0.000001) and colour (p=0.005) of the lesions for low- vs. mixed or high-risk HPV types. For example, acuminate lesions were mostly found among men with low-risk HPV types, whereas macular lesions were over-represented among them with mixed or high-risk types. The HPV type distribution is similar to that in earlier studies, but we also found correlations with some clinical parameters.
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