A1 Refereed original research article in a scientific journal
METAL ION-PROMOTED HYDROLYSIS OF URIDINE 2',3'-CYCLIC MONOPHOSPHATE - EFFECT OF METAL-CHELATES AND UNCOMPLEXED AQUO IONS
Authors: KUUSELA S, LONNBERG H
Publisher: JOHN WILEY & SONS LTD
Publication year: 1992
Journal:: Journal of Physical Organic Chemistry
Journal name in source: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
Journal acronym: J PHYS ORG CHEM
Volume: 5
Issue: 12
First page : 803
Last page: 811
Number of pages: 9
ISSN: 0894-3230
DOI: https://doi.org/10.1002/poc.610051205
Abstract
The effect of a wide variety of metal ions and metal ion complexes on the hydrolysis of uridine 2',3'-cyclic monophosphate was studied over the pH range 4.5-8.0. The greatest rate accelerations observed were 10(7)-10(8)-fold. The kinetic data obtained are interpreted in terms of a mechanism involving a rapid monodentate binding of the metal ion to the monoanionic phosphodiester and a subsequent intracomplex participation of the metal-bound hydroxo ligand, either as a nucleophile attacking the tetracoordinated phosphorus or as a base facilitating an intermolecular attack of a water molecule. No effect on the product distribution between uridine 2'- and 3'-monophosphates was observed.
The effect of a wide variety of metal ions and metal ion complexes on the hydrolysis of uridine 2',3'-cyclic monophosphate was studied over the pH range 4.5-8.0. The greatest rate accelerations observed were 10(7)-10(8)-fold. The kinetic data obtained are interpreted in terms of a mechanism involving a rapid monodentate binding of the metal ion to the monoanionic phosphodiester and a subsequent intracomplex participation of the metal-bound hydroxo ligand, either as a nucleophile attacking the tetracoordinated phosphorus or as a base facilitating an intermolecular attack of a water molecule. No effect on the product distribution between uridine 2'- and 3'-monophosphates was observed.
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