Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a In-111-radiolabelled monoclonal antibody, 11B6 - UTU Research Portal

A1 Refereed original research article in a scientific journal

Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a In-111-radiolabelled monoclonal antibody, 11B6

Authors: Timmermand OV, Ulmert D, Evans-Axelsson S, Pettersson K, Bjartell A, Lilja H, Strand SE, Tran TA

Publisher: SPRINGER HEIDELBERG

Publication year: 2014

Journal: EJNMMI Research

Journal name in source: EJNMMI RESEARCH

Journal acronym: EJNMMI RES

Article number: ARTN 51

Volume: 4

Number of pages: 12

ISSN: 2191-219X

DOI: https://doi.org/10.1186/s13550-014-0051-5

Abstract

Conclusions: Our study demonstrates the potential of In-111-DTPA-11B6 for the detection of metastatic prostate cancer and monitoring anti-androgen therapy, as it exhibits an increased uptake and accumulation in viable tumour when compared to normal tissue. A humanised version of the 11B6 monoclonal antibody is currently under evaluation.