A1 Refereed original research article in a scientific journal
Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a In-111-radiolabelled monoclonal antibody, 11B6
Authors: Timmermand OV, Ulmert D, Evans-Axelsson S, Pettersson K, Bjartell A, Lilja H, Strand SE, Tran TA
Publisher: SPRINGER HEIDELBERG
Publication year: 2014
Journal: EJNMMI Research
Journal name in source: EJNMMI RESEARCH
Journal acronym: EJNMMI RES
Article number: ARTN 51
Volume: 4
Number of pages: 12
ISSN: 2191-219X
DOI: https://doi.org/10.1186/s13550-014-0051-5
Conclusions: Our study demonstrates the potential of In-111-DTPA-11B6 for the detection of metastatic prostate cancer and monitoring anti-androgen therapy, as it exhibits an increased uptake and accumulation in viable tumour when compared to normal tissue. A humanised version of the 11B6 monoclonal antibody is currently under evaluation.