A1 Refereed original research article in a scientific journal

Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data



Authors: Intosalmi J, Ahlfors H, Rautio S, Mannerstom H, Chen ZJ, Lahesmaa R, Stockinger B, Lahdesmaki H

Publisher: BIOMED CENTRAL LTD

Publication year: 2015

Journal: BMC Systems Biology

Journal name in source: BMC SYSTEMS BIOLOGY

Journal acronym: BMC SYST BIOL

Article number: ARTN 81

Volume: 9

Number of pages: 12

ISSN: 1752-0509

DOI: https://doi.org/10.1186/s12918-015-0223-6(external)


Abstract

Conclusions: Our results show significant evidence, for instance, for inhibitory mechanisms between the transcription factors and reveal a previously unknown dependency between the dosage of the inducing cytokine TGFa and the expression of the master regulator of competing (induced) regulatory T cell lineage. Further, our experimental validation approves this dependency in Th17 polarizing conditions.




Last updated on 2024-26-11 at 13:28