Refereed journal article or data article (A1)

Blockage of collagen binding to integrin alpha 2 beta 1: structure-activity relationship of protein-protein interaction inhibitors

List of Authors: Koivunen JT, Nissinen L, Juhakoski A, Pihlavisto M, Marjamaki A, Huuskonen J, Pentikainen OT


Publication year: 2011

Journal: MedChemComm

Journal name in source: MEDCHEMCOMM

Journal acronym: MEDCHEMCOMM

Volume number: 2

Issue number: 8

Start page: 764

End page: 770

Number of pages: 7

ISSN: 2040-2503


The interaction between the alpha 2 beta 1 integrin and collagen plays a crucial role in the development of pathological conditions, such as thrombus formation and cancer cell metastasis. Accordingly, the alpha 2 beta 1 integrin is a promising target for the development of new drug molecules to treat these diseases. Here, we have designed, synthesized, and measured in vitro a set of novel drug-like compounds that block the protein-protein interactions between alpha 2 beta 1 integrin and collagen. The obtained structure-activity relationship reveals the key features that are required for successful inhibition of this integrin-collagen interaction.

Last updated on 2022-18-03 at 14:10