The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men

: Saarinen A, Valimaki VV, Valimaki MJ, Loyttyniemi E, Auro K, Uusen P, Kuris M, Lehesjoki AE, Makitie O

Publisher: ELSEVIER SCIENCE INC

: 2007

BONE

: BONE

: 40

: 4

: 1006

: 1012

: 7

: 8756-3282

DOI: https://doi.org/10.1016/j.bone.2006.11.010

Conclusion: The polymorphic valine variant at position 1330 of LRP5 was significantly associated with reduced BMC and BMD values in healthy young Finnish men. The results provide evidence for the crucial role of LRP5 in peak bone mass acquisition. (c) 2006 Elsevier Inc. All rights reserved.

Internal medicine