A1 Refereed original research article in a scientific journal
Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response
Authors: Kuparinen T, Seppala I, Jylhava J, Marttila S, Aittoniemi J, Kettunen J, Viikari J, Kahonen M, Raitakari O, Lehtimaki T, Hurme M
Publisher: NATURE PUBLISHING GROUP
Publication year: 2012
Journal: Genes and Immunity
Journal name in source: GENES AND IMMUNITY
Journal acronym: GENES IMMUN
Number in series: 2
Volume: 13
Issue: 2
First page : 184
Last page: 190
Number of pages: 7
ISSN: 1466-4879
DOI: https://doi.org/10.1038/gene.2011.71
Abstract
Cytomegalovirus (CMV) causes an infection, which is followed by a lifelong latency. CMV has received much attention in clinical studies, but little is known about the genetic basis of this common infection. To identify genetic polymorphisms associated with the susceptibility to and strength of anti-CMV immunoglobulin G (IgG) response to CMV infection, we conducted a genome-wide association study (GWAS) using an Illumina BeadChip containing 670 000 probes and participants from the Cardiovascular Risk in Young Finns Study, including 1486 anti-CMV IgG seropositive and 648 seronegative individuals. Statistical analyses were performed using logistic (for susceptibility) and linear regression (for strength of antibody response). None of single-nucleotide polymorphisms (SNPs) was found to be associated with susceptibility to CMV infection at the level of genome-wide significance (P<5 x 10(-8)). Also, none of the association signals identified reached genome-wide levels of statistical significance in the study of the strength of the antibody response to CMV although five SNPs in AGBL1 gene region displayed a suggestive association (lowest P-value = 1.86 x 10(-6)). The results indicate that there is no strong evidence of major host genetic factors involved in either susceptibility to or the strength of antibody response to human CMV infection. Genes and Immunity (2012) 13, 184-190; doi:10.1038/gene. 2011.71; published online 13 October 2011
Cytomegalovirus (CMV) causes an infection, which is followed by a lifelong latency. CMV has received much attention in clinical studies, but little is known about the genetic basis of this common infection. To identify genetic polymorphisms associated with the susceptibility to and strength of anti-CMV immunoglobulin G (IgG) response to CMV infection, we conducted a genome-wide association study (GWAS) using an Illumina BeadChip containing 670 000 probes and participants from the Cardiovascular Risk in Young Finns Study, including 1486 anti-CMV IgG seropositive and 648 seronegative individuals. Statistical analyses were performed using logistic (for susceptibility) and linear regression (for strength of antibody response). None of single-nucleotide polymorphisms (SNPs) was found to be associated with susceptibility to CMV infection at the level of genome-wide significance (P<5 x 10(-8)). Also, none of the association signals identified reached genome-wide levels of statistical significance in the study of the strength of the antibody response to CMV although five SNPs in AGBL1 gene region displayed a suggestive association (lowest P-value = 1.86 x 10(-6)). The results indicate that there is no strong evidence of major host genetic factors involved in either susceptibility to or the strength of antibody response to human CMV infection. Genes and Immunity (2012) 13, 184-190; doi:10.1038/gene. 2011.71; published online 13 October 2011
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