Vertebral bone marrow glucose uptake is inversely associated with bone marrow fat in diabetic and healthy pigs: [18F]FDG-PET and MRI study - UTU Research Portal

A1 Refereed original research article in a scientific journal

Vertebral bone marrow glucose uptake is inversely associated with bone marrow fat in diabetic and healthy pigs: [18F]FDG-PET and MRI study

Authors: Huovinen V., Saunavaara V., Kiviranta R., Tarkia M., Honka H., Stark C., Laine J., Linderborg K., Tuomikoski P., Badeau R., Knuuti J., Nuutila P., Parkkola R.

Publication year: 2014

Journal: BONE

Journal name in source: Bone

Volume: 61

First page : 33

Last page: 38

Number of pages: 6

ISSN: 8756-3282

DOI: https://doi.org/10.1016/j.bone.2013.12.022

Abstract

Objectives: Diabetes induces osteoporosis and during osteoporosis, vertebral bone marrow (VBM) adipose tissue amount increases. The association between this adiposity and bone marrow metabolism is unclear. Here, we compared VBM glucose metabolism and fat content in healthy and diabetic pigs, in vivo, using positron emission tomography (PET), in-phase and out-of-phase magnetic resonance imaging and magnetic resonance proton spectroscopy (H MR spectroscopy).

Materials/methods: Eleven pigs (n=11) were used. The intervention group had five diabetic and the control group had six healthy pigs. To measure metabolism, PET-imaging with [F]fluoro-deoxy-glucose ([F]FDG) intravenous tracer was used. 1.5-T MRI with H spectroscopy, in-phase and out-of-phase imaging and chemical TAG analysis of the VBM were performed.

Results: We found a significant inverse correlation between VBM glucose uptake (GU) and VBM fat content (R=-0.800, p<0.01) and TAG concentration assay (R=-0.846, p<0.05). There was a trend, although non-significant, of a linear correlation between VBM H MR spectroscopy and TAG concentration (R=0.661) and H MR spectroscopy and in-phase and out-of-phase MR imaging (R=0.635).