A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Adiponectin is related with carotid artery intima-media thickness and brachial flow-mediated dilatation in young adults-The Cardiovascular Risk in Young Finns Study
Tekijät: Saarikoski L A, Huupponen R K Viikari J S A, Marniemi J Juonala M, Kähönen M, Raitakari O T
Kustantaja: INFORMA HEALTHCARE
Julkaisuvuosi: 2010
Journal: Annals of Medicine
Tietokannassa oleva lehden nimi: ANNALS OF MEDICINE
Lehden akronyymi: ANN MED
Numero sarjassa: 8
Vuosikerta: 42
Numero: 8
Aloitussivu: 603
Lopetussivu: 611
Sivujen määrä: 9
ISSN: 0785-3890
DOI: https://doi.org/10.3109/07853890.2010.514284
Tiivistelmä
Aims. Adiponectin may be involved in the pathogenesis of atherosclerosis. We investigated the relation of adiponectin on early functional and structural markers of subclinical atherosclerosis in a large population-based cohort of young men and women.Methods and results. We measured serum adiponectin using radioimmunoassay in 2,147 young adults (ages 24-39 years) participating in the Cardiovascular Risk in Young Finns Study. The subjects had ultrasound data on carotid intima-media thickness (IMT), carotid artery elasticity (n = 2,139) and brachial flow-mediated dilatation (FMD) (n = 1,996). In univariate analysis, adiponectin was inversely associated with IMT (r = -0.16, P < 0.0001) and directly with FMD (r = 0.12, P < 0.0001) and carotid elasticity (r = 0.20, P < 0.0001). The associations for IMT and FMD remained significant in multivariable models adjusted for age, sex, obesity indices, serum lipids, blood pressure, leptin, glucose, and C-reactive protein: IMT (beta = -0.018 +/- 0.005, P = 0.0002) and FMD (beta = 0.72 +/- 0.25, P = 0.004). The relation between adiponectin and carotid elasticity attenuated to non-significant after adjusting for waist circumference and systolic blood pressure.Conclusion. In young healthy adults, low serum adiponectin concentration is independently related with increased carotid IMT and attenuated brachial FMD, supporting the role of adiponectin in the pathogenesis of early atherosclerosis.
Aims. Adiponectin may be involved in the pathogenesis of atherosclerosis. We investigated the relation of adiponectin on early functional and structural markers of subclinical atherosclerosis in a large population-based cohort of young men and women.Methods and results. We measured serum adiponectin using radioimmunoassay in 2,147 young adults (ages 24-39 years) participating in the Cardiovascular Risk in Young Finns Study. The subjects had ultrasound data on carotid intima-media thickness (IMT), carotid artery elasticity (n = 2,139) and brachial flow-mediated dilatation (FMD) (n = 1,996). In univariate analysis, adiponectin was inversely associated with IMT (r = -0.16, P < 0.0001) and directly with FMD (r = 0.12, P < 0.0001) and carotid elasticity (r = 0.20, P < 0.0001). The associations for IMT and FMD remained significant in multivariable models adjusted for age, sex, obesity indices, serum lipids, blood pressure, leptin, glucose, and C-reactive protein: IMT (beta = -0.018 +/- 0.005, P = 0.0002) and FMD (beta = 0.72 +/- 0.25, P = 0.004). The relation between adiponectin and carotid elasticity attenuated to non-significant after adjusting for waist circumference and systolic blood pressure.Conclusion. In young healthy adults, low serum adiponectin concentration is independently related with increased carotid IMT and attenuated brachial FMD, supporting the role of adiponectin in the pathogenesis of early atherosclerosis.
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