Interleukin-10 gene promoter region polymorphisms are not associated with BCG osteitis in vaccinated infants - UTU Research Portal

A1 Refereed original research article in a scientific journal

Interleukin-10 gene promoter region polymorphisms are not associated with BCG osteitis in vaccinated infants

Authors: Poyhonen L, Terasjarvi J, Nuolivirta K, Vuononvirta J, Grondahl-Yli-Hannuksela K, Kroger L, Huhtala H, Mertsola J, Ilonen J, Peltola V, Korppi M, He Q

Publisher: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)

Publication year: 2015

Journal: International Journal of Tuberculosis and Lung Disease

Journal name in source: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Journal acronym: INT J TUBERC LUNG D

Volume: 19

Issue: 10

First page : 1158

Last page: 1162

Number of pages: 5

ISSN: 1027-3719

DOI: https://doi.org/10.5588/ijtld.15.0348(external)

Abstract

CONCLUSION: Our results suggest that polymorphisms of the IL-10 encoding gene do not play a central role in the development of complications due to BCG vaccination, although the IL10 gene, especially IL10 rs1800896 (-1082G/A) polymorphism, is known to be associated with tuberculosis risk in Europeans and North Americans.