Acetaminophen Improves Analgesia but Does Not Reduce Opioid Requirement After Major Spine Surgery in Children and Adolescents

: HILLER A, HELENIUS I, NURMI E, NEUVONEN PJ, Kaukonen M, HARTIKAINEN T, KORPELA R, TAIVAINEN T, MERETOJA OA

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 2012

: Spine

: SPINE

: 20

: 37

: 20

: E1225

: E1231

: 7

: 0362-2436

DOI: https://doi.org/10.1097/BRS.0b013e318263165c

Conclusion. IV-administered acetaminophen 90 mg/kg/day, adjuvant to oxycodone, did improve analgesia, but did not diminish oxycodone consumption during 24 hours after major spine surgery in children and adolescents. All acetaminophen concentrations were in nontoxic levels.