A1 Refereed original research article in a scientific journal
Acetaminophen Improves Analgesia but Does Not Reduce Opioid Requirement After Major Spine Surgery in Children and Adolescents
Authors: HILLER A, HELENIUS I, NURMI E, NEUVONEN PJ, Kaukonen M, HARTIKAINEN T, KORPELA R, TAIVAINEN T, MERETOJA OA
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2012
Journal: Spine
Journal name in source: SPINE
Journal acronym: SPINE
Number in series: 20
Volume: 37
Issue: 20
First page : E1225
Last page: E1231
Number of pages: 7
ISSN: 0362-2436
DOI: https://doi.org/10.1097/BRS.0b013e318263165c(external)
Conclusion. IV-administered acetaminophen 90 mg/kg/day, adjuvant to oxycodone, did improve analgesia, but did not diminish oxycodone consumption during 24 hours after major spine surgery in children and adolescents. All acetaminophen concentrations were in nontoxic levels.