A1 Refereed original research article in a scientific journal
METAL-IONS THAT PROMOTE THE HYDROLYSIS OF NUCLEOSIDE PHOSPHOESTERS DO NOT ENHANCE INTRAMOLECULAR PHOSPHATE MIGRATION
Authors: KUUSELA S, LONNBERG H
Publisher: JOHN WILEY & SONS LTD
Publication year: 1993
Journal:: Journal of Physical Organic Chemistry
Journal name in source: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
Journal acronym: J PHYS ORG CHEM
Volume: 6
Issue: 6
First page : 347
Last page: 356
Number of pages: 10
ISSN: 0894-3230
DOI: https://doi.org/10.1002/poc.610060606
Abstract
The effects of several metal ions and metal ion complexes on the hydrolysis and interconversion of uridylyl(2',5')uridine and its 3',5'-isomer were studied as a function of pH and metal ion concentration. The hydrolysis was shown to be markedly accelerated by Zn2+, Cd2+ and trivalent lanthanide ions and by tri- and tetraaza complexes of Zn2+. In contrast, none of these species appreciably promotes the interconversion of the 2',5'- and 3',5'-isomers, in spite of the fact that this reaction proceeds through the same pentacoordinated intermediate as the hydrolysis. Lanthanide ions also promote the hydrolytic dephosphorylation of uridine 2'- and 3'-monophosphates, but have a barely noticeable effect on their interconversion. The mechanisms of the metal ion-promoted reactions are discussed.
The effects of several metal ions and metal ion complexes on the hydrolysis and interconversion of uridylyl(2',5')uridine and its 3',5'-isomer were studied as a function of pH and metal ion concentration. The hydrolysis was shown to be markedly accelerated by Zn2+, Cd2+ and trivalent lanthanide ions and by tri- and tetraaza complexes of Zn2+. In contrast, none of these species appreciably promotes the interconversion of the 2',5'- and 3',5'-isomers, in spite of the fact that this reaction proceeds through the same pentacoordinated intermediate as the hydrolysis. Lanthanide ions also promote the hydrolytic dephosphorylation of uridine 2'- and 3'-monophosphates, but have a barely noticeable effect on their interconversion. The mechanisms of the metal ion-promoted reactions are discussed.
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