A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Mandibular reconstruction using free bone flap after preoperative chemoradiation
Tekijät: Irjala H, Kinnunen I, Aitasalo K
Kustantaja: SPRINGER
Julkaisuvuosi: 2012
Journal: European Archives of Oto-Rhino-Laryngology
Tietokannassa oleva lehden nimi: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
Lehden akronyymi: EUR ARCH OTO-RHINO-L
Numero sarjassa: 5
Vuosikerta: 269
Numero: 5
Aloitussivu: 1513
Lopetussivu: 1518
Sivujen määrä: 6
ISSN: 0937-4477
DOI: https://doi.org/10.1007/s00405-011-1795-4
Tiivistelmä
When treating head and neck cancer of an advanced stage, additional therapy modalities are often combined with surgery. This sets new challenges for the reconstructive surgery, especially after segmental mandibulectomy. There is continuous discussion considering the optimal timing of the surgery with relation to other treatment methods such as radiation therapy and chemotherapy. In this work, we have analyzed a series of 10 patients treated with segmental mandibulectomy and preoperative irradiation or chemoradiation in our institute between 1999 and 2006. Surgery was scheduled within 5 weeks from the radiation therapy. 9 out of 10 reconstruction flaps were vital at the last follow-up. In general the outcome of these patients was consistent with the results published earlier by other institutes using postoperative irradiation or chemoradiation. We conclude that preoperative irradiation does not have negative impact on microvascular reconstruction with free bone flap and this procedure offers an equal option for the treatment of these patients.
When treating head and neck cancer of an advanced stage, additional therapy modalities are often combined with surgery. This sets new challenges for the reconstructive surgery, especially after segmental mandibulectomy. There is continuous discussion considering the optimal timing of the surgery with relation to other treatment methods such as radiation therapy and chemotherapy. In this work, we have analyzed a series of 10 patients treated with segmental mandibulectomy and preoperative irradiation or chemoradiation in our institute between 1999 and 2006. Surgery was scheduled within 5 weeks from the radiation therapy. 9 out of 10 reconstruction flaps were vital at the last follow-up. In general the outcome of these patients was consistent with the results published earlier by other institutes using postoperative irradiation or chemoradiation. We conclude that preoperative irradiation does not have negative impact on microvascular reconstruction with free bone flap and this procedure offers an equal option for the treatment of these patients.
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