A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring: The Environmental Determinants of Diabetes in the Young (TEDDY) study
Tekijät: Jimin Yang, Roy N. Tamura, Carin A. Aronsson, Ulla M. Uusitalo, Åke Lernmark, Marian Rewers, William A. Hagopian, Jin-Xiong She, Jorma Toppari, Anette G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Jill M. Norris, Suvi M. Virtanen, Daniel Agardh; and The Environmental Determinants of Diabetes in The Young study group
Kustantaja: CAMBRIDGE UNIV PRESS
Julkaisuvuosi: 2017
Journal: British Journal of Nutrition
Tietokannassa oleva lehden nimi: BRITISH JOURNAL OF NUTRITION
Lehden akronyymi: BRIT J NUTR
Vuosikerta: 117
Numero: 3
Aloitussivu: 466
Lopetussivu: 472
Sivujen määrä: 7
ISSN: 0007-1145
eISSN: 1475-2662
DOI: https://doi.org/10.1017/S0007114517000332
Perinatal exposure to nutrients and dietary components may affect the risk for coeliac disease (CD). We investigated the association between maternal use of vitamin D, n-3 fatty acids (FA) and Fe supplements during pregnancy and risk for CD autoimmunity (CDA) and CD in the offspring. Children at increased genetic risk were prospectively followed from birth in The Environmental Determinants of Diabetes in the Young (TEDDY) study. CDA was defined as having persistently positive tissue transglutaminase autoantibodies (tTGA). Diagnosis of CD was either biopsy-confirmed or considered likely if having persistently elevated levels of tTGA >100 AU. Of 6627 enrolled children, 1136 developed CDA at a median 3.1 years of age (range 0.9-10) and 409 developed CD at a median 39 years of age (range 1.2-11). Use of supplements containing vitamin D, n-3 FA and Fe was recalled by 66, 17 and 94 % of mothers, respectively, at 3-4 months postpartum. The mean cumulative intake over the entire pregnancy was 2014 mu g vitamin D (sd 2045 mu g), 111 g n-3 FA (sd 303 g) and 8806 mg Fe (sd 7017 mg). After adjusting for country, child's human leucocyte antigen genotype, sex, family history of CD, any breast-feeding duration and household crowding, Cox's proportional hazard ratios did not suggest a statistically significant association between the intake of vitamin D, n-3 FA or Fe, and risk for CDA or CD. Dietary supplementation during pregnancy may help boost nutrient intake, but it is not likely to modify the risk for the disease in the offspring.
