A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy
Tekijät: Tibor Z. Veres, Tamás Kopcsányi, Marko Tirri, Armin Braun, Masayuki Miyasaka, Ronald N. Germain, Sirpa Jalkanen, Marko Salmi
Kustantaja: NATURE PUBLISHING GROUP
Julkaisuvuosi: 2017
Journal: Scientific Reports
Tietokannassa oleva lehden nimi: SCIENTIFIC REPORTS
Lehden akronyymi: SCI REP-UK
Artikkelin numero: 694
Vuosikerta: 7
Sivujen määrä: 9
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-017-00769-6
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/20538454
The mucosal layer of conducting airways is the primary tissue exposed to inhaled microorganisms, allergens and pollutants. We developed an in vivo two-photon microscopic approach that allows performing dynamic imaging studies in the mouse trachea, which is a commonly used in vivo model of human small-diameter bronchi. By providing stabilized access to the tracheal mucosa without intubation, our setup uniquely allows dynamic in vivo imaging of mucociliary clearance and steady-state immune cell behavior within the complex airway mucosal tissue.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
