A1 Journal article – refereed

An oral challenge test with carmine red (E120) in skin prick test positive patients

List of Authors: Liippo J, Lammintausta K

Publication year: 2015

Journal: European Annals of Allergy and Clinical Immunology

Volume number: 47

Issue number: 6

Number of pages: 5

ISSN: 1764-1489



Positive skin prick test reactions to carmine red (E120) occur in approximately 3% of the patients studied for food allergy. Carmine ingestion associated systemic symptoms are occasionally suspected, but sufficient information of proven carmine allergy is not available.


To analyse carmine related symptoms in skin prick test positive patients a cohort of 23 patients with suspected allergy to carmine red was subjected to a single-blind placebo-controlled oral challenge test with carmine red.


Five patients developed clinical symptoms during the placebo-controlled oral challenge. As a result, the overall frequency of clinical carmine allergy is estimated to be 0.7% in general dermatology patients studied for food-associated symptoms.


Oral challenge test provides a valuable in vivo tool to better inform patients with positive skin prick tests to additives to avoid false allergy diets.

Last updated on 2021-24-06 at 10:46