Population-Based Input Function Modeling for [F-18]FMPEP-d(2), an Inverse Agonist Radioligand for Cannabinoid CB1 Receptors: Validation in Clinical Studies

: Zanotti-Fregonara P, Hirvonen J, Lyoo CH, Zoghbi SS, Rallis-Frutos D, Huestis MA, Morse C, Pike VW, Innis RB

Publisher: PUBLIC LIBRARY SCIENCE

: 2013

: PLoS ONE

: PLOS ONE

: ARTN e60231

: 8

: 4

: 7

: 1932-6203

DOI: https://doi.org/10.1371/journal.pone.0060231

Conclusions: Despite being initially well validated in healthy subjects, PBIF may misrepresent clinical protocol results and be a source of variability between different studies and institutions.