A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Genome-wide association study identifies multiple loci influencing human serum metabolite levels




TekijätKettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, Lyytikainen LP, Kangas AJ, Soininen P, Wurtz P, Silander K, Dick DM, Rose RJ, Savolainen MJ, Viikari J, Kahonen M, Lehtimaki T, Pietilainen KH, Inouye M, McCarthy MI, Jula A, Eriksson J, Raitakari OT, Salomaa V, Kaprio J, Jarvelin MR, Peltonen L, Perola M, Freimer NB, Ala-Korpela M, Palotie A, Ripatti S

KustantajaNATURE PUBLISHING GROUP

Julkaisuvuosi2012

JournalNature Genetics

Tietokannassa oleva lehden nimiNATURE GENETICS

Lehden akronyymiNAT GENET

Numero sarjassa3

Vuosikerta44

Numero3

Aloitussivu269

Lopetussivu276

Sivujen määrä10

ISSN1061-4036

DOIhttps://doi.org/10.1038/ng.1073


Tiivistelmä
Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of serum samples. We identified significant associations (P < 2.31 x 10(-10)) at 31 loci, including 11 for which there have not been previous reports of associations to a metabolic trait or disorder. Analyses of Finnish twin pairs suggested that the metabolic measures reported here show higher heritability than comparable conventional metabolic phenotypes. In accordance with our expectations, SNPs at the 31 loci associated with individual metabolites account for a greater proportion of the genetic component of trait variance (up to 40%) than is typically observed for conventional serum metabolic phenotypes. The identification of such associations may provide substantial insight into cardiometabolic disorders.



Last updated on 2024-26-11 at 17:36