A2 Refereed review article in a scientific journal
Estrogens and bladder outlet obstruction
Authors: Li XD, Rahman N
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 2010
Journal: Journal of Steroid Biochemistry and Molecular Biology
Journal name in source: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Journal acronym: J STEROID BIOCHEM
Number in series: 4-5
Volume: 118
Issue: 4-5
First page : 257
Last page: 263
Number of pages: 7
ISSN: 0960-0760
DOI: https://doi.org/10.1016/j.jsbmb.2009.10.014
Abstract
Increasing evidence indicates a direct interrelationship between benign prostatic hyperplasia and chronic non-bacterial prostatic inflammation in the development of human voiding dysfunction in aging male, which gradually transforms to bladder outlet obstruction (BOO). Increased prevalence of BOO along with the aging process further suggests that estrogen or more precisely decreased androgen to estrogen ratio in serum is involved in the pathogenesis of BOO. In this review, we will analyze the hormonal causes, clinical relevance, and biologically relevant estrogen-modulated animal models potential for BOO study. In light of the data presented in this review, it becomes apparent that direct inhibition of estrogen action may provide important pharmaceutical treatment of the BOO. (C) 2009 Elsevier Ltd. All rights reserved.
Increasing evidence indicates a direct interrelationship between benign prostatic hyperplasia and chronic non-bacterial prostatic inflammation in the development of human voiding dysfunction in aging male, which gradually transforms to bladder outlet obstruction (BOO). Increased prevalence of BOO along with the aging process further suggests that estrogen or more precisely decreased androgen to estrogen ratio in serum is involved in the pathogenesis of BOO. In this review, we will analyze the hormonal causes, clinical relevance, and biologically relevant estrogen-modulated animal models potential for BOO study. In light of the data presented in this review, it becomes apparent that direct inhibition of estrogen action may provide important pharmaceutical treatment of the BOO. (C) 2009 Elsevier Ltd. All rights reserved.
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