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TRIBUTYLTIN INHIBITION OF ADRENERGICALLY ACTIVATED SODIUM PROTON-EXCHANGE IN ERYTHROCYTES OF RAINBOW-TROUT (ONCORHYNCHUS-MYKISS)
Tekijät: VIRKKI L, NIKINMAA M
Kustantaja: ELSEVIER SCIENCE BV
Julkaisuvuosi: 1993
Journal: Aquatic Toxicology
Tietokannassa oleva lehden nimi: AQUATIC TOXICOLOGY
Lehden akronyymi: AQUAT TOXICOL
Vuosikerta: 25
Numero: 1-2
Aloitussivu: 139
Lopetussivu: 146
Sivujen määrä: 8
ISSN: 0166-445X
DOI: https://doi.org/10.1016/0166-445X(93)90025-V
Tiivistelmä
In the present study, the effect of TBT on the adrenergically activated Na+/H+ exchange in rainbow trout erythrocytes was investigated. TBT was found to inhibit the isoproterenol-induced efflux of protons, uptake of Na+ and Cl- ions, and cell swelling. This indicates that TBT affects the activity of the Na+/H+ exchanger. The inhibitory effect of TBT apparently depended on the haematocrit value of the red cell suspension, which may indicate that TBT distributes preferentially to cell membranes where the agent interacts with the Na+/H+ exchanger.
In the present study, the effect of TBT on the adrenergically activated Na+/H+ exchange in rainbow trout erythrocytes was investigated. TBT was found to inhibit the isoproterenol-induced efflux of protons, uptake of Na+ and Cl- ions, and cell swelling. This indicates that TBT affects the activity of the Na+/H+ exchanger. The inhibitory effect of TBT apparently depended on the haematocrit value of the red cell suspension, which may indicate that TBT distributes preferentially to cell membranes where the agent interacts with the Na+/H+ exchanger.
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